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Freelance translator and/or interpreter, Verified member
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English to Spanish: Cutaneous Manifestations of Systemic Disease General field: Medical Detailed field: Medical: Health Care
Source text - English It is important to not think of the skin as an isolated organ. Many systemic disorders have an associated skin involvement including autoimmune connective tissue disease and sarcoidosis, where cutaneous signs can aid in diagnosis. There are also primary skin conditions with secondary systemic involvement such as autoimmune
blistering disease. Examples of these and further evaluation and management are reviewed here.
1. Lupus
1.1. Background1,2
• Multisystem autoimmune disorder, characterized by presence of multiple antibodies.
• Skin involvement can be seen in up to 85% of patients with lupus; cutaneous signs make up four of the major criteria of systemic lupus erythematosus (SLE).
• Cutaneous lupus can be subdivided into three categories: acute, subacute, and chronic. Chronic cutaneous lupus contains multiple subtypes, including discoid lupus, that have different clinical manifestations.
1.2. Clinical Presentation
• Acute cutaneous lupus erythematosus (ACLE)
• Bilateral malar erythema, classically sparing the nasolabial folds following sun exposure
• May also occur as a generalized photosensitive eruption, often involving the extensor forearms and dorsal hands
• Is a manifestation of SLE
• Subacute cutaneous lupus erythematosus (SCLE) (Fig. 10-1)
• Annular pink, scaly plaques, typically photodistributed on the upper chest and back.
• Drug-induced variant: known drug triggers include hydrochlorothiazide, terbinafine, calcium channel blockers, nonsteroidal anti-inflammatory drugs (e.g., naproxen), griseofulvin, and antihistamines.
• Neonatal lupus is a form of SCLE in neonates that can occur in mothers with anti-SSA antibodies. The eruption is similar to that of SCLE, with a predilection for the scalp and periorbital areas. Internal organ involvement can be seen with congenital heart block (with a mortality of 20% if untreated), hepatobiliary disease, and thrombocytopenia.
Translation - Spanish Es importante no pensar en la piel como un órgano aislado. Numerosas enfermedades sistémicas presentan una afección de la piel asociada, incluyendo enfermedades autoinmunitarias, del tejido conjuntivo y la sarcoidosis, en las cuales los signos cutáneos ayudan al diagnóstico. También existen alteraciones cutáneas primarias con compromiso sistémico secundario, como la enfermedad ampollosa autoinmunitaria. En este capítulo se comentan ejemplos de estas enfermedades, así como su valoración y tratamiento.
1. LUPUS
1-1. Antecedentes1,2
• Enfermedad autoinmunitaria multisistémica caracterizada por la presencia de múltiples anticuerpos.
• Se observan afecciones cutáneas hasta en el 85% de los pacientes con lupus; los signos cutáneos constituyen cuatro de los criterios mayores para el diagnóstico de lupus eritematoso sistémico (LES).
• El lupus cutáneo puede subdividirse en tres categorías: agudo, subagudo y crónico. El lupus cutáneo crónico incluye varios subtipos, como el lupus discoide, que presenta diferentes manifestaciones clínicas.
1-2. Presentación clínica
• Lupus eritematoso cutáneo agudo (LECA)
• Eritema malar bilateral que, de forma clásica, deja intactos los pliegues nasolabiales después de la exposición al sol.
• También puede presentarse como una erupción fotosensible generalizada que con frecuencia afecta la superficie extensora de los antebrazos y el dorso de las manos.
• Se trata de una manifestación del LES.
• Lupus eritematoso cutáneo subagudo (LECS) (fig. 10-1)
• Placas escamosas rosadas anulares, por lo general, fotodistribuidas en la parte superior del tórax y la espalda.
• Variante inducida por fármacos: algunos desencadenantes farmacológicos conocidos incluyen hidroclorotiazida, terbinafina, antagonistas del calcio, antiinflamatorios no esteroideos (p. ej., naproxeno), griseofulvina y antihistamínicos.
• El lupus neonatal es una forma de LECS que se presenta en recién nacidos de madres con anticuerpos anti-SSA. La erupción es similar a la del LECS, con predilección por el cuero cabelludo y las áreas periorbitarias. El daño de órganos internos incluye bloqueo cardíaco congénito (con mortalidad del 20% si no se trata), enfermedad
hepatobiliar y trombocitopenia.
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Translation education
Master's degree - Universidad de Buenos Aires
Experience
Years of experience: 18. Registered at ProZ.com: Sep 2020. Became a member: Sep 2020.
Credentials
Spanish (Universidad de Buenos Aires, verified) English to Spanish (Universidad Nacional de Buenos Aires)
Memberships
N/A
Software
Adobe Acrobat, Adobe Illustrator, Adobe Photoshop, Indesign, memoQ, MemSource Cloud, Microsoft Excel, Microsoft Word, Trados Studio
My translator and editor career started in 2006, when I began working as a freelancer in Editorial Médica Panamericana, at first for the Mexican branch and then for the headquarters in Argentina. After obtaining my Master's Degree in Discourse Analysis from the University of Buenos Aires in 2012, I returned to Mexico and founded Doctores de Palabras, a publishing agency that provides editorial services to the largest medical publishers worldwide (WK/LWW, Elsevier, McGraw-Hill, Cengage, Océano). During these years I have translated, edited, and/or supervised more than 25,000,000 characters, including over 100 books (many of which are classics, e.g., Snell, Bates, Ross, Porth) and countless articles. I have devoted my entire career to provide high quality services as a means to allow Spanish speaking soon-to-be doctors and nurses to learn through clearly and precisely written texts in their own language, at the same time helping my customers to attain their goals.
Member since Sep '20
Blue Board entries made by this user