Sep 29, 2021 00:55
2 yrs ago
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English term
me-too drug
GBK
English to Chinese
Medical
Medical (general)
Definition from
PubMed:
Me-too drugs can be broadly defined as chemically related to the prototype, or other chemical compounds which have an identical mechanism of action.
Example sentences:
An advantage of having several related drugs on the market is that patients and doctors have the option of trying several compounds to obtain the compound with the fewest adverse effects and best therapeutic efficacy in individual cases, although we suspect that this does not often happen. Me-too drugs can be useful in cases of an adverse reaction to an excipient in another drug formulation. (British Pharmaceutical Society Journals)
About 60 percent of the World Health Organization’s listed essential medicines, for example, are me-too drugs, and estimates of the number of new drugs approved by the FDA have been as high as 75 percent. (Center of American Progress)
On the other hand, the more differentiated me-too drugs are from pioneering drugs, the greater their potential benefits, and the less they harm the incentives for pioneering research. (Research Gate)
Change log
Sep 24, 2021 14:53: changed "Kudoz queue" from "In queue" to "Public"
Sep 29, 2021 00:55: changed "Stage" from "Preparation" to "Submission"
Oct 2, 2021 01:57: changed "Stage" from "Submission" to "Selection"
Oct 9, 2021 01:54:
Oct 29, 2021 01:54:
Nov 28, 2021 01:54:
Proposed translations
+1
20 hrs
派生药
Definition from
新浪财经:
该类药物是针对已知靶点设计的与已经存在药物结构不同的新药，虽然也是仿照原研药，但稍微改变了原研药的化学结构，因此也叫“派生药”。
Example sentences:
Me-too药又叫派生药，在我国市场临床用药占80%。虽然仿照原研药，但稍微改变原研药的化学结构。例如，现在市场上有7种他汀，严格意义上讲都是来源于美伐他汀的派生药。 (搜狐)
相对于动辄几亿美元的突破性创新性药物研发，仿制则显现出巨大的性价比，化药有1类药，3类药，从定义上看，1类药属于未在国内外上市销售的药品，但是大多数一类创新药并不是严格意义上的突破性创新药，基本上是me-too药，这又叫派生药，改变化学结构的方式获得专利，质量达到一定要求还可以名正言顺的返销发达国家。 (知乎)
随着对生理生化机制的了解，得到了一些疾病治疗的突破性药物，这些药物不仅在医疗效果方面，而且在医药市场上也取得了较大的成功，这些药物通常被称为原型药物（prototype drug）。随之出现了大量的"me-too"药物。"me-too"药物特指具有自己知识产权的药物，其药效和同类的突破性的药物相当。这种旨在避开“专利”药物的产权保护的新药研究，大都以现有的药物为先导物进行研究。研究的要点是找到不受专利保护的相似的化学结构，这种研究有时可能得到比原“突破性”药物活性更好或有药代动力学特色的药物。 例如兰索拉唑及其他的拉唑的研究是以奥美拉唑为先导物的，其活性比奥美拉唑活性更强。 (百度)
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